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Neuropathology (NP) Data Download Guide – ADRC Portal

Introduction​

Alzheimer’s Disease Research Centers (ADRCs) can access and download Neuropathology (NP) data submitted to the National Alzheimer’s Coordinating Center (NACC) through the ADRC Portal.

There are two ways to view and download NP data:

  • Accessing project wide NP data downloads through the audit interface
  • Viewing NP data within the participant-level forms interface, alongside other modules (e.g., UDS and retrospective forms)

This guide explains how to access and download NP data using both methods.

Method 1: Downloading NP Data for an Entire Center​

This method allows ADRCs to download all NP submissions for their center using the audit interface. This approach is useful when performing:

  • Data quality review
  • Center wide data exports
  • Programmatic data analysis

Step-by-step guide​

Step 1: Open the Audit Interface​

From the ADRC Portal homepage, click View, Audit, and Access Participant Data.

Alt text: np download 01 portal home view audit tile.

Step 2: Open the UDS Data Export Page​

Select the tile for the UDS Data Export interface (name may vary slightly depending on the final release). This page displays all form submissions across the center, including retrospective modules such as NP.

Alt text: np download 02 uds data export tile.

Step 3: Filter for NP Modules​

Within the module submissions interface, locate the Filter by Module. Select NP (Neuropathology) to display only NP submissions. This view shows a table containing NP submissions for your center.

Alt text: np download 03 filter by module.

Alt text: np download 04 module filter np.

Step 4: Review NP Submission Records​

The filtered table lists NP submissions and may include fields such as:

  • NACCID
  • Module name
  • QC status

Users can apply additional filters if needed (for example, filtering only records that failed QC).

Alt text: np download 05 np module table.

Step 5: Download the NP Dataset​

To export the displayed NP records, click the Download UDS Data (.zip) button. This will download a zip file containing the currently visible rows, including any active filters.

Alt text: np download 06 download np dataset.

Method 2: Viewing and Downloading NP Data for Individual Participants​

This method allows users to review NP data associated with a specific participant visit. The NP module appears in the participant’s list of submitted forms alongside other modules.

Step-by-step guide​

Step 1: Open the Participant Data Page​

From the top level of the ADRC Portal, click UDS, LBD, FTLD, & NP Data in the sidebar.

Alt text: np download 07 sidebar uds lbd ftld np.

Step 2: Locate a Participant​

Navigate to the participant search interface and locate the participant whose data you want to review. You can locate participants by:

  • Searching by Participant ID (PTID) or NACCID
  • Using available search filters

Alt text: np download 08 participant search.

Step 3: Select the Participant​

Select the participant or type to search for a participant from the results list to open their participant record.

Alt text: np download 09 select participant.

Step 4: View Milestones and Visits​

After selecting a participant, the Participant Summary Page will appear. This page displays participant information and all associated visits and modules. Within the Milestones and Visits section, you will see all submitted modules for that participant, including the Neuropathology (NP) module if NP data has been submitted.

Alt text: np download 10 participant milestones visits.

Step 5: Open the NP Module​

Select the NP module associated with the visit. The module page displays:

  • The QC status of the submission
  • The submission date
  • All raw data fields from the uploaded NP file

Alt text: np download 11 np module visit details.

Step 6: Download NP Data​

To download the NP data for this visit, click the Download Form CSV button. This downloads the NP module data for that participant visit as a CSV file.

Alt text: np download 12 download form csv.

Step 7: Review QC Status (Optional)​

Each module submission displays a QC status indicator. The QC status helps determine whether the submission passed or failed automated data checks. Typical indicators include:

  • PASS – The submission passed QC validation
  • FAIL – The submission failed QC validation and may require review

Users can open the QC details page to review validation results and identify issues if a submission fails QC. To do this, click on the Module QC status (e.g., PASS), as shown in the screenshot below.

Alt text: np download 13 module qc status pass button.

Then, in the Visit-Level QC Status panel, you can review the QC status for each participant (PTID) and each record in the submitted files. For example, click PASS in the QC Status column.

Alt text: np download 14 visit level qc status pass.

The interface will then display the QC Status, such as:

  • Identifier Lookup: Retrieves participant identifiers for the incoming data.
  • Form CSV to JSON Transformer: Converts the form data from CSV to JSON.
  • Form QC Coordinator: Coordinates validation across visits/modules for a given participant.
  • Form QC Checker: Runs NACC data quality checks on a participant’s visit record.

Alt text: np download 15 visit level qc status pass details.

Summary of NP Data Access Options​

  • Audit / Module Forms Interface (Method 1)

    Used when downloading all NP submissions for a center, or when performing data quality review.

  • Participant View (Method 2)

    Used when reviewing or downloading NP data for a specific participant visit.

Both options provide flexible access depending on whether you need center-wide NP datasets or targeted participant-level data.

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