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NIAGADS GWAS Data

This document outlines how to access GWAS data through the ADRC portal. The data itself is stored in Flywheel projects for your center.

Accessing GWAS Data Through the ADRC Portal​

  1. Log into the ADRC Portal.

Alt text: Image of the ADRC Portal Landing Page

  1. Click on the "View, Audit, and Access Participant Data" button.

Alt text: Image of ADRC Portal Landing page with the "View, Audit, and Access Participant Data" button outlined

  1. Click on the "ADGC & NIAGADS (Genetic/Genomic)" button.

Alt text: Image of the ADRC Portal "View, Audit, and Access Participant Data" landing page with the "ADGC & NIAGADS (Genetics/Genomic)"" button outlined

  1. Select the data type you wish to access.

    If the button is grayed out, that means you do not have access to the corresponding Flywheel project. Contact your center's administrator or director to request access.

Alt text: Image of the ADRC Portal "ADGC & NIAGADS (Genetics/Genomic)" page with the "GWAS Data" and "Imputation Data" buttons outlined

  1. Each button will bring you to the corresponding data type's landing page, which lists the files available for your center along with a brief summary about the data and how it was generated. The data for each genotyping round is contained in a tar.gz archive.

Alt text: Image of the ADRC Portal "GWAS Data" page showing example GWAS data from the Sample Center

  1. To download the data, click on one of the download icons next to the data files, which will bring up the downloads dialogue for that specific file.

Alt text: Image of the ADRC Portal "GWAS Data" page showing example GWAS data from the Sample Center with the download icon for a single file outlined

  1. Click on the "Generate Download Link" button. This generates a download link that expires in 24 hours. Clicking on the link will start the download process for that specific file.

    Due to the size of the data, some files may take a long time to download. Be sure to double check the size of the archive before downloading.

Alt text: Image of the download dialogue for ADC1_0.tar.gz, with the "Generate Download Link" button highlighted

Alt text: Image of the download dialogue for ADC1_0.tar.gz, with the generated download link.

  1. Once the file is downloaded, you will need to extract the individual files from the archive. The easiest way to do that is in a terminal with the tar command, replacing filename.tar.gz with the name of your file.
    1. For machines where a terminal is not easily accessible, or a GUI is preferred, you can also use a third-party file archiver such as 7-Zip or WinZip.
tar xzf filename.tar.gz

The above will extract the contents to the same directory. To extract to a specific directory, use the -C flag:

tar xzf filename.tar.gz -C path/to/target/dir