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NIAGADS GWAS Data

This document outlines how to access GWAS data through the ADRC portal. The data itself is stored in Flywheel projects for your center.

Accessing GWAS Data Through the ADRC Portal​

  1. Log into the ADRC Portal.

Alt text: Image of the ADRC Portal Landing Page

  1. Click on the "View, Audit, and Access Participant Data" button.

Alt text: Image of ADRC Portal Landing page with the "View, Audit, and Access Participant Data" button outlined

  1. Click on the "ADGC & NIAGADS (Genetic/Genomic)" button.

Alt text: Image of the ADRC Portal "View, Audit, and Access Participant Data" landing page with the "ADGC & NIAGADS (Genetics/Genomic)"" button outlined

  1. Select the data type you wish to access.

    If the button is grayed out, that means you do not have access to the corresponding Flywheel project. Contact your center's administrator or director to request access.

Alt text: Image of the ADRC Portal "ADGC & NIAGADS (Genetics/Genomic)" page with the "GWAS Data" and "Imputation Data" buttons outlined

  1. Each button will bring you to the corresponding data type's landing page, which lists the files available for your center along with a brief summary about the data and how it was generated. The data for each genotyping round is contained in a tar.gz archive.

Alt text: Image of the ADRC Portal "GWAS Data" page showing example GWAS data from the Sample Center

  1. To download the data, click on one of the download icons next to the data files; this will open up the corresponding Flywheel project.

    The Flywheel project page may take a bit to load.

Alt text: Image of the ADRC Portal "GWAS Data" page showing example GWAS data from the Sample Center with the download icon for a single file outlined

  1. Scroll down to "Attachments". Under "Actions" click the three stacked dots for the file you want to download and click "Download". The download will begin through your browser.

    Due to the size of the data, some files may take a long time to download. Be sure to double check the size of the archive before downloading.

Alt text: Image of the corresponding "Distribution GWAS NIAGADS" Flywheel project with "Attachments", "Actions", and "Download" components are outlined.

  1. Once the file is downloaded, you will need to extract the individual files from the archive. The easiest way to do that is in a terminal with the tar command, replacing filename.tar.gz with the name of your file.
    1. For machines where a terminal is not easily accessible, or a GUI is preferred, you can also use a third-party file archiver such as 7-Zip or WinZip.
tar xzf filename.tar.gz

The above will extract the contents to the same directory. To extract to a specific directory, use the -C flag:

tar xzf filename.tar.gz -C path/to/target/dir